Sartobind® Phenyl membrane adsorbers use the principles of hydrophobic interaction chromatography (HIC) for large-scale purification of biomolecules. As there is virtually no diffusion limitation of mass transport thanks to the novel, macroporous convective membrane matrix, Sartobind Phenyl accomplishes polishing and capturing five to ten times faster than do conventional HIC resins. The membrane shows comparable, high binding capacity, without size exclusion effects, for proteins in a range of 20 mg mAb/ml membrane, as well as excellent resolution and impurity reduction.